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Abstract

DEVELOPMENT OF TOPICAL FORMULATION CONTAINING ALLOPHYLUS COBBE L. FOR WOUND HEALING ACTIVITY

*Sanjeevani Desai, Pravin Sathe and John Disouza

ABSTRACT

Wound healing is a complex multifactorial process that results in the contraction and closure of the wound and restoration of functional barrier. Allophylus cobbe L. leaves are widely used in Indian medicine to cure wounds, burns. However, complete evaluation of these activities is absent. Thus, the present study aimed to assess the wound healing activity of Allophylus cobbe L. leaves in topical ointment formulation. The emulsifying ointment formulations containing extracts of the above mentioned herb was formulated, evaluated and their wound healing activity was studied on experimentally induced excision open wounds in albino rats. The effects of the formulation on wound healing were assessed by the rate of wound closure, period of epithelialization and histopathology. The methanol extract of Allophylus cobbe L. Leaves (1 g) was incorporated into 10 g of a simple ointment base by melting and triturating to give two batches of each the both hydrophilic and hydrophobic ointment formulation. The pH, viscosity, spreadability, stability studies and skin irritation test were determined. The measurement of the wound areas were taken up-to 18th days and the percentages of wound closures were calculated. Blank ointment base and Gentamycin ointment (1% w/w) served as the control and standard treatments. The prepared ointments passed all the physical evaluation parameters. There were no changes in pH, viscosity, spreadability and consistency when the ointments were kept at different temperatures for 90 days. These formulations did not produce any skin irritation. Topical application of the prepared ointment on the excision wound in rats caused a significantly (p<0.05) higher rate of wound healing and reduced the epithelialization period in a doserelated manner. The tissue histology of ointment treated group showed complete epithelialization with increased collagenation, compared to the (1%) Gentamycin ointment. The formulated ointments were evaluated and effective in wound care and should be explored in harnessing the potentials of the plant in the treatment of Topical diseases.

Keywords: Wound healing, Herbal formulation, Allophylus cobbe L., Excision wound.


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