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Abstract

FORMULATION AND EVALUATION OF FLOATING MICROBALLONS OF REPAGLINIDE

G. Uma Rani*, R. Nagaraju and T. Lakshmi Rao

ABSTRACT

Novel drug delivery system as a major advance to solving the problems related to the release of the drug at specific site. In recent years, in oral sustained or controlled release multiparticulate drug delivery system extensive research works have been occurs because of its advantages over monolithic dosage form. Now a day’s floating concept of multiparticulate reservoir type delivery system more importance. These systems have several advantages over conventional multi dose therapy. There are various approaches in delivering a therapeutic substance to the target site in a sustained release fashion. One such approach is using Microballons as carriers for drugs. Microencapsulation is used to modify and delay drug release from pharmaceutical dosage forms. The present aim of study is to increase the solubility and permeability of drug to control of blood glucose values, Hence Repaglinide is formulated in the form of floating Microballons and inspite of having higher half life it is controlled mainly for inhibiting irregular release pattern of the drug. The model drug for Microballons was taken as repaglinide and the formulation were done with different ratios of polymers Eudragit RLPO and Eudragit RSPO taking Methanol and dichloromethane as solvent system, The best formulation was found to be F12 with eudragit RLPO which showed an entrapment efficiency of 65.87% and drug release of 96.57% for 24 hrs. The formulated Microballons were evaluated for Incorporation efficiency, Surface morphology of Microballons, Particle size analysis, Buoyancy Percentage and In vitro release.

Keywords: Repaglinide, Floating Microballons, solvent evapor


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