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Abstract

EVALUATION OF HEPATOPROTECTIVE AND ANTIPYRETIC ACTIVITY OF ETHANOLIC EXTRACT OF

Asish Bhaumik, P. Sravan Kumar* and Monica Chopra

ABSTRACT

Herbal medicines have recently attracted much attention as alternative medicines useful for treating or prevent in life style related disorders and relatively very little knowledge is available about their mode of action. There has been a growing interest in the analysis of plant products which has stimulated intense research on their potential health benefits. Moringa oleifera is a small, fast-growing evergreen or deciduous tree that usually grows as high as 9 m. with a soft and white wood and with corky and gummy bark. Roots have the taste of horseradish. Leaves are longitudinally cracked. Leaves have long main axis (30-75 cm) and jointed branch. The main objective of the present research work was extraction of phytoconstituents from ethanolic extract of root of Moringa oleifera root and evaluation of in vivo hepatoprotective and antipyretic activity. The in vivo hepatoprotective activity was carried out againast CCl4 induced rat hapatocytes and in vivo antipyretic activity was done by Brewer´s yeast induced fever in rats. The experimental data of present research work displayed that the group-II (CCl4 in liquid paraffin (30% v/v) (1ml/kg, i. p) animals showed significant (P<0.01) increase in SGPT (117.33±6.56), SGOT (309.5±6.21), ALP (398.83± 33.31), Total Bilirubin (0.69±0.02) and decrease in Total Portion (7.48±0.24) levels, whereas animals received EMOE significantly (P<0.01) reduced levels of SGPT (79.96±3.65, 80.76±3.23), SGOT (286.23±9.41, 299.33±2.90), ALP (306.1±20.36, 285.33±5.4), Total Bilirubin (0.29±0.01, 0.25±0.008), and significantly (P<0.05) increased Total protein levels (7.42±0.19, 7.55±0.05) at 200 & 400 mg/kg doses respectively. The levels of SGPT (78.66±1.73), SGOT (230.86±4.20), ALP (283.23±31.68), Total Bilirubin (0.29±0.03), and significantly (P<0.01) decreased and increased total protein levels (7.45±0.11) by the administration of Liv-52 (1ml/kg, p. o) as a standard drug. The ethanolic extract of Moringa oleifera lam significantly (P<0.01) reversed yeast induced pyrexia in rats throughout the observation period up to 6 h. The reference drug aspirin also suppressed fever induced by yeast in rats.

Keywords: Deciduous, phytoconstituents, hepatoprotective and antipyretic activity, ALP etc.


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