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Abstract

FORMULATION AND EVALUATION OF OFLOXACIN ORODISPERSIBLE TABLET BY SUBLIMATION TECHNIQUE

P.R.Radhika*, Javed and T.Sivakumar


ABSTRACT

The rational demand for mouth dissolving has been growing, especially for geriatric and pediatric patients because of swallowing difficulties. In the present work, Orodispersible tablets of Ofloxacin were designed with a view to enhance patient compliance by sublimation method. In this method camphor was used as a sublimation agent (up to 20 % w/w), Kyron T314, and Crosscarmellose sodium (2-8% w/w) used as Superdisintegrants. The prepared formulation was evaluated for weight variation, hardness, friability, drug content, wetting time, and invitro dissolution. All the formulations showed low weight variation with dispersion time of less than 80 seconds and rapid invitro dissolution seen in formulation F3. The results revealed that the tablets containing more quantity of sublimating agents and super disintegrants had a good dissolution profile. The drug content of all the formulations were within the acceptable limits of the USP XXVII. The optimized formulation showed good release profile with maximum drug being released at all time intervals. It was concluded that Orodispersible tablets with improved Ofloxacin dissolution could be prepared by sublimation of tablets containing suitable sublimating agent and disintegrants. This work helped in understanding the effect of formulation processing variables especially the sublimating agent and disintegrants on the drug release profile.

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