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Abstract

PREPRATION AND IN VITRO EVALUATION OF PIMOZIDE MUCOADHESIVE TRANSDERMAL DOSAGE FORMS

Gururaj S. Kulkarni*, Shivakumar Swamy , Chandrasekhar Narajji, Yogesh H S

ABSTRACT

Oral drug delivery is most convenient route of dosage form administration but it has some disadvantages. Overcome these short coming new dosage forms are developed for better bioavailability and therapeutic effects of therapeutic agents. In this study we have made an attempt to develop a transdermal patch for pimozide drug for short duration with better absorption. Transdermal is a route for administration of therapeutic agents for systemic drug delivery. Pimozide a anti-psychotic agent with less dose (1 to 10 mg). Transdermal patches of Pimozide were prepared using HPMC (15 & 47 cps), carbopol 934, poly vinyl alcohol, and poly vinyl pyrolidone polymers in different concentrations. Study of UV spectrophotometer and FTIR revealed that there is no interaction between pimozide and polymers. The patches were evaluated for their thickness uniformity, folding endurance, weight uniformity, content uniformity, swelling behavior, tensile strength, and surface pH. In vitro release studies of pimozide-loaded patches in phosphate buffer pH 7.4 exhibited drug release in the range of 91.15 to 101.25 % in 120 min. Data of in vitro release from patches were fit in to different equations and kinetic models to explain release kinetics. The models used were zero and first-order equations, Hixon-Crowell, Higuchi and Korsmeyer-Peppas models.. In vivo studies in rabbits showed 85.97% of drug absorption from HPMC-15 cps patch in 90 min. Good correlation among in vitro release and in vivo absorption of pimozide was observed.

Keywords: Pimozide; transdermal patches; in vitro release; evaluation.


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