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Abstract

FORMULATION DEVELOPMENT OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE BILAYERED TABLETS USING NATURAL GUMS

*Ananda Kumar Chettupalli

ABSTRACT

Hyperglycemia is the technical term for high blood glucose (sugar). It happens when the body has too little or not enough insulin or when the body can‘t use insulin properly. The main objective of the present research work was to develop a bilayer tablet of immediate release Pioglitazone and controlled release Metformin Hydrochloride, which is used as an Anti-hyperglycemic agent. Metformin Hydrochloride has biological half-life nearly about 6 hours, so, an attempt was made in the direction of preparation and optimization of a combination of sustained release and immediate release in a single tablet. In controlled release layer natural gums like xanthum gum, gum trgacanth and guar gum were used as retarding materials and in immediate release laye croscarmellose sodium was used as a superdisintegrent to give the faster release of pioglitazone. The tablets were prepared by wet granulation method and by direct compression. Granules were evaluated for precompression parameters and the tablets were evaluated for post compression parameters.

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