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Abstract

THE EFFECTS OF ERCC1 EXPRESSION LEVELS ON THE CHEMORESISTANCE OF BREAST CANCER PATIENTS TREATED WITH PLATINUM-BASED ADJUVANT CHEMOTHERAPY.

Suhad Khalid Karim*, Ban Abaas Abd. AL Majeed, Muhammad Ibraheem Nader

ABSTRACT

Excision repair cross-complementing 1 (ERCC1) is reported to be involved in the sensitivity of cancer patients to platinum-based chemotherapy. The present study was evaluate the effects of ERCC1 expression on the chemosensitivity of platinum agents in breast cancer. ERCC1 expression levels were measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The results demonstrated patients with low ERCC1 levels had chemosensitive than those with high ERCC1 levels. These results suggest that overexpression of ERCC1 is correlated with platinum drug resistance in breast cancer patients. The patients with low levels of ERCC1 expression demonstrate a benefit from platinum-based adjuvant chemotherapy.

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