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Abstract

AN EFFICIENT ONE-POT SYNTHESIS OF N-(3-(BENZOFURAN-3- YL)-3-OXO-1-PHENYLPROPYL) ACETAMIDE SCAFFOLDS VIA MULTICOMPONENT REACTION: AS A NOVEL CLUSTER OF FREE RADICAL, OXIDATION AND BACTERIAL INHIBITORS

Javarappa Rangaswamy, Honnaiah Vijay Kumar and Nagaraja Naik*

ABSTRACT

A series of N-(3-(benzofuran-3-yl)-3-oxo-1-phenylpropyl)acetamide scaffolds (4a-j) were synthesized by multicomponent one pot reaction. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, mass, elemental analysis and further screened for their in vitro antioxidant and antibacterial activities. All the synthesized scaffolds in this series showed comparably high, equal or less activity to the corresponding standard. Among them interestingly, compound 4g was observed to be an effective antioxidant. However, compounds 4i and 4e exhibited moderate antioxidant potency, while compounds 4d and 4f exhibited maximum bacterial inhibition effect. Resulting in the finding that, these classes of derivatives have displayed the significant antioxidant and antibatcterial activity.

Keywords: N-(3-(benzofuran-3-yl)-3-oxo-1-phenylpropyl)acetamide scaffolds, substituted benzaldehyde, antioxidant activity, antibacterial activity.


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