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Abstract

METHOD DEVELPOMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ARTESUNATE AND MEFLOQUINE IN PURE AND PHARMACEUTICAL DOSAGE FORM

Shweta D. Sonawane*, S. R. Bavaskar and Dr. S. D. Barhate

ABSTRACT

A simple, rapid, accurate and precise development and validation of RP-HPLC method for the simultaneous estimation of Artesunate and Mefloquine in bulk and combined tablet dosage form. forms. ThermoBDS column (250mm×4.6mm, id) 5 μm particle size was used as stationary phase. The mobile phase used was Acetonitrile:Buffer POT.Phos. Buffer (60:40v/v) at pH7.2. A flow rate of 0.7 ml/min was delivered. UV detection was set at 230 nm. Retention time for ART and MEF was found to be 2.91 min and 9.37 min respectively. The linearity was observed over the range of 4-20mcg/ml and 5-25mcg/ml for ART and MEF respectively. The correlation co-efficient found to be 0.998 and 0.998 for ART and MEF respectively. Moreover, the %RSD for repeatability, Inter and intra-day precision was found to be less than 2% which reveals method is precise. The %recovery was found to be 101.00% for ART and 100.25% for MEF. The assay percentage was found to be 100.68% and 103.65% for ART and MEF respectively. All the validation parameters were checked according to ICH guidelines.

Keywords: Artesunate and Mefloquine, RP-HPLC Method, Validation.


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