WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF KETOCONAZOLE PRONIOSOMAL GEL

G. V. Radha*, U. Manasa and R. Krishna Chaitanya

ABSTRACT

Proniosomes are water-soluble carrier particles that are coated with surfactant and can be measured out as needed and dehydrated to form niosomal dispersion immediately before use on brief agitation in hot aqueous media within minutes. Provesicular systems, such as proniosomes which is one of the advancement in nanotechnology minimize problems of vesicular systems. This research mainly emphasizes on formulating Ketoconazole Proniosomal gels with span surfactants, cholesterol, soya lecithin and alcohol as aqueous phase. These are prepared by coacervation phase separation method and the prepared formulations are characterized for FTIR studies, Encapsulation efficiency, size distribution and In vitro release studies were carried. FTIR studies showed that there was no interaction between API and used excipient. The encapsulation efficiency of Proniosomal formulations are in the range of 55% to 69.94%. Morphological size and shape of the vesicles are characterized by using optical microscopy and scanning electron microscopy, particles are found to be spherical, size of the particles are in the range of 3.29μm to 30μm and permeation studies showed good control release for prolonged period of time. Span20 Non lecithin formulation showed highest amount of drug release of 74% in 24 hours.The results suggest that ketoconazole proniosome formulations can be used for Topical drug delivery system for the treatment of skin infections.

Keywords: Proniosomal Gel, Ketoconazole, Nanotechnology, Formulation.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More