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Abstract

AZATHIOPRINE EFFECTS ON KIDNEY AND LIVER IN FRUCTOSEINDUCED DIABETIC RAT (WISTAR)

*Farangis Ghassemi, Roh Allah Ardeshir, Golshid Ahmadi, Abas Hoshmandi

ABSTRACT

Background : Azathioprine is an immunosuppressive drug that widely administered in the clinic for multiple uses (autoimmune diseases, post-transplant immunosuppression and cancer ).Using this drug cause complications like toxicity in some organs. Method: 56 Wistar rat weighing 200±20 gr were classified in 8 groups. Control (without treatment) and sham (140cc fructose 10% as a daily feeding). Groups 1 to 4 (diabetic) in addition froctose 10 % feeding, were injected (3.75, 7.5, 15 and 21) mg/kg/b.wt azathioprine interaperitoneal at 98th day. Groups 5 and 6 (adiabatic) were injected (15 and 21) mg/kg/b.wt azathioprine interaperitoneal. 24 hours after, blood samples were taken from all groups and their serum separated for biochemical analyzes. Data were analyzed by ANOVA and Duncan test (P<0.01). Results: Obtained finding showed that serumic amounts of blood glucose, Triglyceride, Total and direct bilirubin, total protein and ALP increased significantly and in all experimental groups and AST, increased in groups 1-4, comparing control group (p<0.01). In the other hand, urea nitrogen, creatinine and cholesterol (HDL) were increased in diabetic groups. Conclusion: Azotioprin is dose- dependent and had synergistic effects with diabetes. Although the effect of this drug on kidney is more than liver but seems diabetes is effective more in this result. Therefore, diabetics are taking limits for consuming Azathiprin.

Keywords: Azatioprin, Tissue damage, Liver enzyme.


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