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Abstract

STUDY OF LEVELS OF LIPOPROTEIN (A) IN CORONARY ARTERY DISEASE AND DIABETES MELLITUS

Dr. Suvarna T. Jadhav*, Dr. Ajit V. Sontakke, Dr. Bipin M. Tiwale, Smita patil

ABSTRACT

Coronary Artery Disease (CAD) leads to Angina and Myocardial Infarction (MI). Premature mortality on Coronary Heart Disease (CHD) is more common in diabetic atherosclerosis. In the present study serum level was Lipoprotein (a) estimated in patients of CAD with DM, CAD without DM, DM without CAD and CAD with DM and other risk factors compared to healthy normal subjects. The level of Lipoprotein (a) was significantly increased in all four groups of patients as compared to control group. Conclusion – Lp (a) acts as atherogenic protein by binding to LDL receptors, it also blocks plasminogen and competes for binding to fibrinogen, thus acting as a prothrombin agent. It inhibits clot lysis.

Keywords: Coronary Artery Disease, Diabetes Mellitus, Lipoprotein (a).


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