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Abstract

SIMULTANIOUS ESTIMATION OF COBICISTAT AND ATAZANAVIR SULPHATE IN BULK AND COMBINED DOSAGE FORM BY UVSPECTROPHOTOMETRIC METHOD

B. Valli Purnima, M. Santha Kumari, G. Ramu, T. Vijaya Bhaskara Reddy, D. Ramachandran*

ABSTRACT

A simple and sensitive ultra-violet spectrophotometric method was developed and validated for the determination of cobicistat (COBI) and atazanavir sulphate (ATV) simultaneously in bulk and pharmaceutical formulations. The developed method was applied to determine the stability of the drugs in the drug sample under different degradation conditions. Wavelength of maximum absorbance of COBI and ATV were found to be 239.3 and 292.5 nm respectively. The system precision and method precision expressed as % RSD of six replicate measurements were found to be 0.3471 & 0.4612 and 0.8695 & 0.8784 for COBI and ATV respectively. The mean percent of recovery for COBI and ATV were found to be in between 100.84 and 100.79. Limit of detection and limit of quantitation were found to be 0.795 & 2.651 and 1.7525 & 5.750 for COBI and ATV respectively. Absorbance was linearly proportional to concentration of COBI and ATV in the range of 7.5-37.5 and 15-75 μg/ml. The assay of the tablet dosage form Evotaz was determined and found to be 99.61 and 100.46% for COBI and ATV respectively. The developed method was adopted for the study of satiability of the drugs under different degradation conditions and percent of degradation was found to be in between 12.74-5.38 and 15.94-6.94 for COBI and ATV respectively. Therefore, the developed method was found to be simple, rapid and applied for the quality control, therefore the proposed method is recommended for the analysis of COBI and ATV in pure and tablet dosage forms in any quality control laboratories.

Keywords: Cobicistat, Atazanavir sulphate, Stability, Assay, Evotaz.


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