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Abstract

FAST DISSOLVING DOSAGE FORMS: AN OVERVIEW

Lohithasu Duppala*, Shabari Girinath K. and D. Midhun Kumar

ABSTRACT

Oral route of administration having the conventional and maximum patient compliance as the most convenient, safest and also the most economical method of drug delivery. Fast dissolving dosage forms are containing medicinal substances which dissolve or disintegrates into smaller granules rapidly in the saliva without water or chewing within few seconds (<60sec) to more than a minute depending on the formulation (due to the action of superdisintegrant or maximizing pore structure in the formulation) and the size for enhancement of patient convenience and compliance and these are advantageous particularly for pediatric, geriatric, psychiatric patients who have difficulty in swallowing conventional tablets and capsules. These type of dosage forms are also ideal for active patients who are traveling and may not have to take water. Fast dissolving dosage forms have gained considerable attention for those patients who have difficulties in swallowing due to dysphagia, hand tremors problems and have additional advantage for unconscious, young patients with underdeveloped muscular and nervous system. The present review describes the various advantages, limitations, desired characteristics, various formulation challenges, super-disintegrants employed; technologies developed for FDTs, evaluation tests.

Keywords: Fast dissolving dosage form, super-disintegrant, saliva.


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