WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

ALPHA CELLS A ‘THERAPEUTIC TARGET’: EFFECT OF CITRULLUS COLOCYNTHIS ON ALPHA CELL COUNT IN HEALTHY AND ALLOXAN INDUCED DIABETIC MALE ALBINO RATS

Alia Amin* and Mohammad Tahir

ABSTRACT

Introduction The molecular mechanism of diabetes involves both the beta and alpha cell dysfunction; however, the molecular mechanisms explaining the role of alpha cells in diabetes remains enigma. Objective: The objective of this research was to study the response of alpha cells to ―Citrullus colocynthis‖ in euglycaemia and experimental hyperglycemia. Methods: Forty eight Albino rats were randomly divided into six groups A1, A2, B1, B2, C1 and C2, each comprising of 8 rats. Diabetes was induced in A2, B2 and C2 with single iv injection of 50 mg/kg Alloxan. Rats having fasting blood glucose greater than 250 mg/dl were labeled as diabetic. Aqueous seed extract of Citrullus colocynthis was given to diabetic rats in groups B2 and C2 and their controls in groups B1 and C1 for 14 days. Results: Alpha cell count was significantly increased (3.706± 0.656; p<0.001) in response to alloxan and it was decreased (Insignificantly) in diabetic rats who received high dose of CCT. Alpha to beta cell ratio was increased in diabetic rats which was improved towards control values after treatment with Citrullus colocynthis. There was increase, though insignificant, in alpha cell count in control rats after CCT treatment. There was no significant effect on islet area and relative tissue body weight index. Conclusion: Citrullus colocynthis regulates alloxan induced alpha cell hyperplasia and alpha to beta cell ratios. Alpha cells respond differently in normal and diabetic rats. Altered alpha cell response offers therapeutic target to alleviate diabetes.

Keywords: Alloxan, diabetes, alpha cells, Citrullus colocynthis.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More