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Nayan N. Vadsola* and Bijal Prajapati


The aim of present work was to formulate and evaluate mouth dissolving tablet of Bambuterol Hydrochloride to minimize the disintegration time and improve % drug release. Bambuterol Hydrochloride is an Antiasthmatic drug. Mouth dissolving tablet was formulated using Camphor as a subliming agent. Sodium deoxycholate and Cross povidone were added as permeation enhancer and as a super-disintegrant respectively. Optimization was done by 32 full factorial design and developed formulation was evaluated for In-vitro drug release study and Ex-vivo diffusion study. Concentration of Camphor and Sodium deoxycholate were selected as independent variables. All formulations were evaluated for properties such as weight variation, hardness, friability, drug content, disintegration time, wetting time study, In-vitro dissolution study, Ex-vivo diffusion study. % In-vitro drug release and % Ex-vivo permeation at 10 min were selected as dependent variables. Analysis of variance was performed for dependent variables. In-vitro release data was fitted to various kinetic models of drug release. Optimized formulation batch (B9) had complies the acceptance criteria and was found to be stable for 1 month. % In vitro drug release and % ex-vivo permeation of optimized formulation were found to be 90% and 78.46% at 10 min respectively.

Keywords: Antiasthmatic drug, Super-disintegrating agent, Sublimation method, Mouth dissolving tablet, 32 full factorial designs.

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