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Abstract

DEVELOPMENT AND VALIDATION OF A NORMAL-PHASE HPTLC METHOD FOR THE SIMULTANEOUS ANALYSIS OF PARACETAMOL AND ONDANSETRON IN FIXED-DOSE TABLETS

Vasubabu Padarthi*, Dr. K. N. Vidyadhar, K. Shalini, M. Harika, K.S.G. Sravanthi and M. Keerthana

ABSTRACT

A new precise method was developed for simultaneous quantification of PARACETAMOL and ONDANSETRON in tablets by HPTLC method. The chromatograms were developed using a mobile phase of Chloroform: Dichloro methane: Methanol (4:6:2) on pre-coated plate of TLC silica gel 60 F254 and quantified by densitometric absorbance mode at 254 nm. The Rf values were 0.69 and 0.61 for Ondansetron and Paracetamol respectively. The linearity of the method was found to be within the concentration range between 1-5 mcg/spot for both Paracetamol and Ondansetron. The lower limits of detection and quantification were 0.0634μg/spot and 0.1921μg/spot for Ondansetron and 0.0112μg/spot and 0.1921μg/spot for Paracetamol. The method was also validated for precision, accuracy and recovery. This developed method was used to analyze fixed dosage tablets (Lupisetron plus, Lupin Ltd) samples of Paracetamol and Ondansetron.

Keywords: Paracetamol, Ondansetron and HPTLC.


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