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Abstract

IN VITRO ANTI-OBESITY AND ANTI-CANCER ACTIVITIES OF DIFFERENT EXTRACTS OF ANNONA SQUAMOSA L. AND FICUS RACEMOSA L. LEAVES.

Uma Sankar Gorla* and K. Ravi Shankar

ABSTRACT

Extracts of Annona squamosa and Ficus racemosa leaves were prepared by continuous soxhlet extraction using ethanol and hexane solvents and thereafter subjected for lipase inhibition assay to evaluate anti obesity activity and XTT assay against human lung cancer cell lines (A-549) and human metastatic breast cancer cell lines (MDAMB- 435S) to estimate anticancer property. All extracts showed their varying inhibition activities by dose dependent manner and the results were statistically significant with p<0.05 by using Dunnett’s Multiple Comparison Test. The hexane extracts of Annona Squamosa and Ficus racemosa showed nearly 98.71 and 97.85% inhibition of lipase enzyme respectively at 100μg/mL tested dose. From the cytotoxic analysis it was found that the hexane extract of Ficus racemosa showed nearly 47.83% A-549 cell line inhibition at 200μg/mL tested dose and ethanolic extract of Annona Squamosa showed nearly 28.53% MDA-MB-435S cell line inhibition at 200μg/mL tested dose. Hexane extracts showed the best lipase inhibitory property which may attribute to anti obesity activity and the screening studies revealed that hexane extract of Ficus racemosa and ethanolic extract of Annona Squamosa were found to be active against A-549 and MDA-MB-435S cell lines respectively. Further investigation is needed to reveal the important biochemical constituents and their mechanism responsible for growth suppression and cell death of cancer cell lines.

Keywords: Annona Squamosa; Ficus racemosa; XTT-assay; Anti Lipase; Anti cancer; Cytotoxic.


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