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Abstract

STUDY OF HISTOPATHOLOGICAL CHANGES AND CARBOHYDRATE METABOLIC PROFILES IN DIABETIC OVRIAN TISSUE TREATED WITH ALOE VERA LEAF GEL EXTRACT IN BLACK RAT (RATTUS RATTUS).

Dr. Bishnu Charan Pradhan* and Dr. Bharat Bhusan Mahapatra

ABSTRACT

The study was carried out using female black rats(Rattus rattus) (200- 220gm). The animals were divided into 3 groups (n=7) receiving different treatments. Biochemical analysis of blood and histopathological study of GI mucosa was done after 25 days. Aqueous extract of Aloe vera gel showed significant compared to control Structure and function of many organs alters in diabetic status. Ovary is important organ of reproductive system and its structure influenced in diabetes. Some antidiabetic and protective plants by correction of hyperglycemia and its disturbances including oxidative stress may decrease the side effect of diabetes mellitus on ovary. Aloe vera has hypoglycemic effect. Thus, in present study, its protective effect on black rat(Rattus rattus) ovary structure was evaluated. One group of mature femaleblack rats(Rattus rattus) was kept as control group. Experimental diabetes was induced by streptozotocin (45mg/kg) in two groups of rats. One of these groups was daily treated by Aloe vera gel (300 mg/kg) for s. Afte25 days r,black 25 days rats (Rattus rattus) sacrificed and their ovaries were removed. The 5-6μ sections were made using paraffin embedding techniques and stained by hematoxylin-eosin and PAS. The numbers of primordial, primary, secondary and tertiary follicles were significantly decreased and atretic follicles significantly increased in diabetic black rats(Rattus rattus) with comparison to control group. The secondary and tertiary follicles diameters were significantly decreased in diabeticblack rats(Rattus rattus). The ovary structure was supported in diabetic black rats(Rattus rattus) by Aloe vera gel administration. The number and diameter of secondary and tertiary follicles were increased. Also Aloe vera gel normalized blood glucose and increased weight of black rats(Rattus rattus) and ovary. The results shown that Aloe vera could have beneficial and supporting effects on ovarian tissue and folliculogenesis if used as a hypoglycemic agent in diabetes.

Keywords: Diabetes Mellitus, Ovary Structure, Aloe Vera Gel, ?-cell and black rat (Rattus rattus).


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