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Abstract

PREVALENCE OF SEIZURE AND PRESCRIBING PATTERNS OF ANTI- EPILEPTIC DRUGS IN NEUROLOGICAL ABNORMALITIES

Ayisha Jasmin K.*, Joji G. Ponnachan, Ridhin Joy and Sheba Baby John

ABSTRACT

Back ground: Epilepsy is a neurological disorder – a physical condition which causes sudden bursts of hyperactivity in the brain. This hyperactivity produces “seizures” which vary from one person to another in frequency and form. In approximately 60-75% of all cases, there are no known identified causes. The identifiable causes includes brain injury, head trauma, brain tumor, stroke etc. So the neurological diseases having strong correlation with developing seizures. Prevalence of seizure and prescribing patterns of anti- epileptic drugs in neurological disorders like stroke, migraine, head injury and meningitis are different. Objectives: To analyses prevalence and prescription pattern of seizure induced by stroke, migraine, head injury and meningitis. To understand the occurrence of seizure and prescribing pattern for a patient after CVA attack. To study the occurrence of early and late onset seizure after CVA. To study age and gender wise prevalence of seizure in neurological abnormalities. Materials and methods: The study was conducted at the department of Neurology department in Karuna Medical College, Chittur, Palakkad. The study was conducted over a period of six months from November 2015to April 2016. The study was designed as a prospective observational study to assess the prevalence of seizure and prescribing pattern of Anti-Epileptic Drugs in patients with neurological abnormalities. A total of 217 subjects were included in the study. The statistical analysis was performed by 2- Tailed Fischer Exact Test and the Odd Ratio was analyzed by Medical Software. A predesigned data collection form was used to collect the prescription details of in-patients and out-patients of department of neurology. Results: Seizure attack occurred more in the patient having CVA i.e. about 36 out of 199 cases and the prevalence was found to be 18.09%. In our study all the meningitis patients developed seizure attack. In case of migraine 6 out of 9 patients developed seizure and the prevalence is 66.66%. The most commonly prescribed AED was found to be Levetriacetam and Phenytoin, and the most common prescribing pattern is mono-therapy. Conclusion: From the study we concluded that neurological disease is associated with occurrence of seizure. There is a relationship between CVA, Head injury, Meningitis and seizure from the odd‟s ratio analysis of more than one (1.696, 2.3191, and 2.29 respectively). Migraine was not prove to have a relationship with occurrence of seizure because the odd‟s ratio was less than one (0.4031).

Keywords: Anti-epileptic drug, cerebrovascular accident, central nervous system Phenytoin, Levitiracetam.


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