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Abstract

FORMULATION AND IN VITRO EVALUATION OF METFORMIN HYDROCHLORIDE DIRECT COMPRESSIBLE TABLET USING BY HICELTM MICROCRYSTALLINE CELLULOSE EXCIPIENT

Monika Tomar*, Amit Raj Sinha, Ajay Kumar Singh and Jilika Shah

ABSTRACT

Metformin hydrochloride is generally used to regulate blood glucose level; It is mainly used for Insulin- dependent mellitus or Type II diabetes. Type II diabetes mellitus acts by decreasing hepatic glucose output and peripheral insulin resistance. Metformin hydrochloride is a very popular high dose pharmaceutical active. It is normally made by wet granulation method. Wet granulation is more time and man power consuming method. The overall objective of the present work was to develop Metformin hydrochloride tablets prepared by direct compression method, using HiCelTM 90M microcrystalline Cellulose. The tablets were evaluated for thickness, weight variation, hardness, friability and In vitro drug release. Mean dissolution time is used to characterize drug release rate of dosage from a dosage form. In this study, Metformin hydrochloride direct compressible tablet are made using HiCelTM 90M grade of microcrystalline cellulose. HiCelTM Microcrystalline Cellulose have good binding capacity with metformin hydrochloride, given good hardness with satisfactory dissolution profile of drug.

Keywords: HiCelTM 90M microcrystalline Cellulose, Direct compression of metformin hydrochloride tablet, Hardness, friability, Dissolution profile.


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