WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

COMPARATIVE ANTIFUNGAL ACTIVITIES OF SPECIFIED AND MODIFIED SECONDARY METABOLITES OF PAEONIA SUFFRUTICOSA ROOT EXTRACT AGAINST AFLATOXIGENIC FUNGUS- ASPERGILLIUS FLAVUS UNDER DIFFERENT CONDITIONS

F. Rehman*, Samya Mairaj and U. K. Jetley

ABSTRACT

Paeony suffraticosa is a well known medicinal plant the worldover. Pharmaceutical importance of paeonia suffraticosa is due to the presence of several valuable secondary metabolites in it. Paeonol is one of the active ingredients of the root homogenate of the plant, showing a wide spectrum activity. The anifungal activity of different concentrations of the alcoholic extract of the specified secondary metabolites and their oxime- form against Aspergillus flavus fungal strains was studied at different conditions of temperature and pH. The (bio) activity index (A.I) was also derived and IC50 obtained for 0.04 to 0.004% concentrations of alcoholic extract of the phenolic compounds and their modified form. The minimum inhibitory concentration (MIC) was also calculated which showed variation with experimental conditions. The results indicate that the fungal strain has different tolerance to solvent, temperature and pH and the above said oxime have good antifungal properties as compared to a standard drug (Fluconazole). The susceptible metabolic pathway was assessed by the determining the structural components glucosamine and ergosterol. The antifungal efficacy could be maintained for longer time only at low temperature.

Keywords: Paeonia suffraticose, aflatoxin, aspergillus flavus, antifungal activity, Richard’s liquid medium.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More