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Arpita Sharma*, Aashima Hooda and Hema Chaudhary


Current research was done to develop a topical formulation with
control relase of drug, reducing the side effects associated with topical
drug delivery and improve the efficacy of product with aid of
microsponges. Cream containing microsponges loaded with
sertaconazole nitrate were prepared by using quasi emulsion solvent
diffusion with different proportions of the polymer (Ethyl cellulose).
The developed microsponges were analyzed for particle size,
production yield, entrapment efficiency and drug content. Scanning
electron microscopic images of microsponges revealed that they are
spherical in shape and contain pores. Pore structure analysis was done
by using mercury intrusion porosimetry technique, which confirmed
the porous nature of microsponges. Microsponges were then
incorporated in to a 2% cream and evaluated for pH, drug content, spreadability, viscosity
and in vitro drug release. The batch F6 was found to be optimal as it shown 70% controlled
drug release in 9 hr that followed Higuchi model.

Keywords: microsponges, ethyl cellulose, sertaconazole nitrate, cream.

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