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Abstract

PIROXICAM SOLID LIPID NANOPARTICLES FOR TRANSDERMAL ADMINISTRATION:- IN-VITRO, EX-VIVO, IN-VIVO STUDIES

Meghana S. Kamble* and Ashok V. Bhosale

ABSTRACT

The aim of the present work is to investigate the suitability of solid lipid nanoparticles of piroxicam for its transdermal application. The PRX SLNs were prepared by high speed homogenization, where Phospholipon®90G and cetyl palmitate were used as lipids and Pluronic® F68 as surfactant. The PRX SLNs were evaluated for entrapment efficiency, particle size, zeta potential, DSC, PXRD. The PRX SLN gel was characterized for in-vitro, ex-vivo skin permeation and in-vivo anti-inflammatory activity. The entrapment efficiency, particle size, zeta potential of PRX SLNS were found to be 74.08 ± 1.54 %, 195 nm, -15.18 mV respectively. PRX SLN gel showed better skin permeation than the marketed gel.

Keywords: NSAID, Solid Lipid Nanoparticles, Piroxicam, Lipid carriers, Transdermal, Anti-inflammatory.


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