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Abstract

PHYTOCHEMICAL INVESTIGATION AND BIOLOGICAL ACTIVITES OF THYMUS DECUSSATUS BENTH. GROWING IN EGYPT

Ehab M. Mostafa, Nevein M. Abdelhady, Mohammed M. Ghoneim, *Atef A. EL-Hela

ABSTRACT

Liquid chromatography coupled with ion spray mass spectrometry in
the tandem mode (LC/MS/MS) with negative ion detection was used
for identification of a variety of phenolic compounds in methylene
chloride fraction of methanol extract of Thymus decussatus Benth.
growing in Egypt using gradient elution analysis. Standard solutions of
phenolic and flavonoid compounds, were studied in negative ion mode
where MS/MS product ion scans revealed that 3, 4'-dimethoxychrysin
is the major component of methylene chloride fraction of Thymus
decussatus Benth., in addition to isolation of salvigenin, apigenin,
luteolin, chrysoeriol 7-O-β-D-glucopyranoside and rutin respectively,
moreover, structure elucidation of the isolated compounds was carried
out by spectroscopic (UV, IR, 1D-NMR) methods. The antimicrobial study of the methanol
extract showed strong effect against the selected microorganisms where screening of
cytotoxic activity revealed the significant cytotoxic activity against Ehrlich ascites carcinoma
cells (EAC), as well as two human cancer cell lines (U251) brain- tumor and (Hepg2) liver
carcinoma cell –lines) respectively.

Keywords: Thymus decussatus Benth., Egypt, phenolic, liquid chromatography, antimicrobial and cytotoxic.


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