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Abstract

RANDOMIZED CLINICAL TRIAL OF DEXMEDETOMIDINE EFFICACY IN COMPARISON WITH KETOROLAC FOR PATIENTS WITH ACUTE RENAL COLIC IN THE EMERGENCY DEPARTMENT

Arash Forouzan, Hassan Motamed*, Ali Delirrooyfard and Mozhdeh Mosaffa

ABSTRACT

Background: To choose an analgesic choice for renal colic patients in the Emergency Department, sometimes is a challenge. This
investigation focuses on comparing efficacy of parenteral dexmedetomidine versus intravenous ketorolac in pain relief of patients with acute renal colic pain. Methods: Two groups were
studied consist of 160 patients in a study design of single blind clinical trial. 18-55 years old patients with acute colicky pain of renal stone
origin which have been referred to Emergency Department were included in the study. The diagnosis were confirmed with non contrast abdominopelvic computed tomography. Case group (80 patients) received single-dose parenteral dexmedetomidine (200mcg/2ml vials)
against the control group (80 patients) which received single-dose parenteral ketorolac (30 mg /ml vials) as gold standard treatment during 10 minutes. The pain score were evaluated with Visual Analogue Pain Scale (VAS) on arrival and 20, 40, 60 min after drug administration. Data analysis established using Mann-whitney U test and independent sample T test in both groups. Results: The study data showed administration of dexmedetomidine is more efficient in renal colic pain control immediately and during 60 minutes after administration rather than ketorolac. Although both ketorolac and dexmedetomidine trial group patients, achieved significant pain reduction in contrast to base line pain score in the minutes of 20 and 40 and 60, but analgesic effect of dexmedetomidine were more significant. (p<0.001). Conclusion: Dexmedetomidine may have been a choice for acute renal colic pain control. Trial registration: Clinical Trials IRCT2015120625402N1.

Keywords: Acute renal colic; Dexmedetomidine; Ketorolac; Visual Analogue Pain Scale (VAS); Pain severity.


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