WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

RP-HPLC METHOD FOR ESTIMATION OF BOSUTINIB IN BULK FORM AS PER ICH GUIDELINES

Vidya L. Chaudhari* and Amol A. Kulkarni

ABSTRACT

An accurate, Precise, Simple and Economical High Performance Liquid Chromatographic method for the estimation of Bosutinib in bulk form has been developed. The drug were resoled using a methanol and potassium dehydrogenase Phosphate Buffer 10 mm ph. 5.9 mixed in a proportion of 90:10 v/v as mobile phase on an Primesil C18 column (Length: 250nm, Diameter: 4.6nm, Particle size: 5μ). The linearity for the method was observed in a concentration range of 10- 50μg/mL with the correlation coefficient of 0.998. The retention time for Bosutinib was found to be 6.9 min. Detection wavelength chosen was 266 nm. The accuracy studies of RP-HPLC method was performed at three different levels, i.e. 80%, 100%, 120% and recovery was found to be in the range of 99.58 to 101.25% for Bosutinib respectively. The method so developed was validated in compliance with the regulatory guidelines by using well developed Analytical method validation tool which comprises with the analytical method validation parameters like Linearity, Accuracy, Method precision, Specificity, System suitability, Robustness and Ruggedness. The results obtained were well within the acceptance criteria.

Keywords: Bosutinib, RP-HPLC, Method development, Validation.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More