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Abstract

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF RANITIDINE HYDROCHLORIDE AND ONDANSETRON HYDROCHLORIDE IN PURE AND TABLET

Arshiya Fatima*, B. Sreedevi, Ramya Sri S. and M. A. Haneef

ABSTRACT

A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Ranitidine and Ondansetron, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Hypersil C18 (4.6×250mm) 5μ column using a mixture of Water and Acetonitrile (50:50) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 244nm. The retention time of the Ondansetron and Ranitidine was 2.0, 4.0±0.02min respectively. The method produce linear responses in the concentration range of 5-25μg/ml of Ondansetron and 93.75-468.75μg/ml of Ondansetron. The method precision for the determination of assay was below 2.0% RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.

Keywords: Ranitidine, Ondansetron, RP-HPLC, validation.


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