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Abstract

NANOCOCHLEATES: A NOVEL APPROACH FOR DRUG DELIVERY

Dharmesh Gol*, Viral Shah

ABSTRACT

Nanocochleate is a unique tailor based system used for microencapsulation and delivery of therapeutics by entrapping them in supramolecular assemblies composed of negatively charged phospholipids and a divalent cation. It is a unique multilayered structure widely used for oral and systemic delivery of wide variety of molecules including genes, vaccines and antigens. This article highlights the history, manufacturing methodology, materials used, stability aspects, characterization, applications and advantages of nanocochleate drug delivery systems over other vesicular systems. In a whole nanocochleate represents a unique technology, suitable for oral and systemic delivery of important chemical and biological therapeutics and promises a potential drug delivery system encouraging the future researchers to explore and advance in this new area of delivery technology.

Keywords: Nanocochleate, liposomes, protein and peptides, vesicular system


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