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Abstract

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF LILIUM CANDIDUM.L IN EXPERIMENTAL ANIMAL MODELS

*N. Indira Devi (M. Pharm), S. Nelson Kumar and C. Rajaram

ABSTRACT

Lilium Candidum (Family liliaceae) commonly known as Madonna lilies is a vigorously growing in India. In the present study a pharmacognostics evaluation of the leaves was undertaken. In addition to the evaluation of physicochemical characteristics; preliminary Phytochemical parameters and pharmacological activities of aqueous extracts has been carried out. The aim of the present study was carried out with the objective of phytochemical screening and to evaluate the hepato protective activity of aqueous extract of L. candidum. Liver is the largest organ in the body which serves as a gland also. It plays an important role in the maintenance of internal environment through its multiple and diverse functions. Any damage to the liver or impairment of its functions leads to injurious effects. Liver diseases (like jaundice) are the common ailments affecting mankind, though no remedy is available in allopathic at present. In the recent past years many medicinal plants are screened for their hepato protective activity and quite a few of them are already successful in entering the market, Hence the present study is planned to find out the hepato protective activity of Lilium Candidum using drug induced hepatotoxicity models like Paracetamol, CCL4 and Acetaminophen induced methods. The rats were divided into five groups with six rats in each for three models. Group I (Control) served as normal and received the vehicle alone (Sterile distilled water, 10 ml/kg, p.o.) for 5 days. Group II (Toxin control) animals on the 3rd and 4th day. Group III and IV were treated with LCM at a dose level of 400 mg/kg and 600 mg/kg body weight p.o. per day respectively for 5 days and on the 3rd and 4th day with hepatotoxic drugs was given 1 h after the treatment of the extract. Group V (Standard) was treated with standard drug silymarin (100 mg/kg p.o.) for 5 days and on the 3rd and 4th day hepatotoxic

Keywords: Lilium candidum, hepato protective activity, serum, total protein, albumin, Blood Urea Nitrogen, Alkaline Phosphate, Aspartate amino transferase, Alanine amino transferase.


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