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Abstract

ā€œDEVELOPMENT AND EVALUATION OF ORAL DISPERSIBLE TABLET OF PROMETHAZINE USING PLANTAGO OVATA SEED MUCILAGE AS A NATURAL SUPERDISINTEGRANTā€

*Jaswal Ritu, Ghosh Niladry, Dr. Angshu Banerjee and Thakur Nisha

ABSTRACT

The need for delivering drugs to patients efficiently with minimum side effects has prompted industries to be engaged in development of new drug delivery systems. Recent advances in technology prompted researchers and scientists to develop oral disintegrating tablets (ODTs) with improved patient convenience and compliance. Mouth dissolving tablet that dissolve or disintegrate rapidly in oral cavity result in solution, is an ultimate remedy for this problem. In addition they give pleasing mouth feeling. An orally dispersible tablet or orally dissolving tablet is a drug dosage form available for a limited range of over-thecounter (OTC) and prescription medications. In the present work, fast disintegrating tablets of promethazine Hcl are designed with a view to enhance patient compliance by direct compression method. In this method mucilage of Plantago ovata is used as superdisintegrant to enhance the after effects and further improve the overall characteristics of the drug used and thus enhancing the overall tablets formulated. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time, the various formulations were tested for the in vitro drug release pattern, short-term stability and drug-excipient interaction (IR spectroscopy). Among the promising formulations, the formulation prepared by using Plantago ovata mucilage emerged as the overall best formulation based on the in vitro drug release characteristics compared to conventional tablets formulation without disintegrant. The studies on the formulations indicate that there are various different methodologies that depict the various aspects of ODT formulation, superdisintegrants and technologies that are developed, along with various drugs explored, evaluation tests and marketed formulations in this field.

Keywords: Promethazine, Plantago ovata mucilage, fast-disintegrating tablets.


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