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Abstract

CYPERMETHRIN INTOXICATES TESTICULAR BIOMARKERS THROUGH OXIDATIVE STRESS IN MATURE WISTAR MALE RAT AND ZINC ALLEVIATES IT

Tuhina Das, Anurag Paramanik, Rini Ghosh, Debjani Chatterjee, Sujata Maiti Choudhury*

ABSTRACT

Cypermethrin, a synthetic pyrethroid pesticide, is used for more than
one decade to control a wide variety of pests in agriculture. The
present study was designed to investigate the toxic effects of
cypermethrin on the male reproductive system of Wistar rats and also
to assess the ameliorative role of zinc under these toxic conditions.
Cypermethrin was administered alone at two dose levels and zinc was
pretreated alone or combined with cypermethrin orally for 14
consecutivedays. Cypermethrin reduced the testicular index, prostatic
index and epididymal index and sperm motility of rats in a dose
dependent manner after the administration of cypermethrin. Significant
increase in testicular malon-di-aldehyde (MDA) and GSSG levels were
seen in the treated group whereas reduced glutathione (GSH) level of
testis were decreased significantly in a dose-dependent manner compared to the control
group. After the administration of cypermethrin, sperm motility, seminal plasma fructose
concentration and testicular acid phosphatase were decreased significantly. Testicular
glutamate pyruvate transaminase (GPT) and testicular glutamate oxaloacetate transaminase
(GOT) levels were increased in cypermethrin intoxicated rats. The beneficial influences of
zinc in attenuating the harmful effects of cypermethrin on male reproductive system of rat
were observed in this study.

Keywords: Cypermethrin; Zinc; Sperm motility; Seminal plasma fructose concentration Testicular acid phosphatase; Antioxidant parameters.


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