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Abstract

FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF AN ANTIDIABETIC DRUG

Megha N. Karemore*, R.C. Gulwade, D.R. Mundhada and S. Bhaskaran

ABSTRACT

To improve patient compliance, mouth dissolving tablets have emerged as an alternative to conventional dosage form. Voglibose is an alpha glucosidase inhibitor given alone or in combination with sulphonylurea for treatment of type 2 Diabetes to control the post prandial blood glucose levels. During this therapy, it is observed that blood glucose levels are increased. Therefore mouth dissolving tablets of voglibose were prepared to overcome this unusual problem and to make use of the inherent advantages of the novel drug delivery system. Voglibose with sodium starch glycolate, cross carmellose sodium and indione 414 were tableted to obtain mouth dissolving tablets. Voglibose tablets containing 10% indion 414 showed maximum drug release and comparable in-vitro release profile as that of marketed formulation. Formulations were subjected to stability studies. Formulations were stable for 4 weeks at 400 C with insignificant change in hardness, friability, disintegration time and in-vitro drug release pattern.

Keywords: Voglibose, mouth dissolving tablet, sodium starch glycolate, cross carmellose sodium, indion 414.


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