WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

MODELING OF HIV/AIDS SURVIVAL AND STAGING USING SURROGATE MARKERS

*P. Venkatesan

ABSTRACT

For staging and survival, guiding treatment decisions and evaluating effectiveness of therapy of HIV/AIDS, CD4 testing is used as the gold standard. It is expensive to use in resource settings and there is a need for a less expensive surrogate marker to replace it. Several markers were studies in the past and Total Lymphocyte counts (TLC) was one the most studied worldwide. Since TLC varies according to ethnic groups, there is a need to assess the suitability for a particular population. This study sought to assess the suitability of TLC as a surrogate marker for CD4 count in Indian population. The data for the study was taken from 395 patients who were referred to a HIV clinical trial and tested for both CD4 count and TLC. The sensitivity, specificity and predictive values of various cut-off points of TLC were calculated. The decision theory based analysis was also carried out for various CD4 counts and their corresponding TLCs. The sensitivity and specificity of TLC in classifying HIV and AIDS based on CD4 as gold standard were about 50% and 95% respectively. Hence we conclude the TLC seems to be not an adequate marker for HIV/AIDS classification in Indian population as the sensitivity was very low.

Keywords: TLC, CD4 count, HIV, AIDS, biomarker, Sensitivity, Specificity.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More