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Abstract

IN-VITRO ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY OF N-BUTANOL FRACTION FROM TELOSMA PALLIDA (ROXB) CRAIB LEAF

Punit R. Bhatt*, Kajal B. Pandya and Navin R. Sheth

ABSTRACT

Telosma pallida (Roxb) Craib (TP) is a perennial climber found
prominently in the region Saurashtra. Traditionally it is described to
neutralize tridosha (vata, pitta, kapha). The plant is fiber-rich and
edible in this region. An In-vitro anti-inflammatory activity was
evaluated for an n-butanol fraction of the TP leaf by two methods i.e.
inhibition of albumin denaturation, Red Blood Cell (RBC) membrane
stabilization method and. An n-butanol fraction (nBF) was found to
show triterpene saponin in the qualitative phytochemical screening. In
the present study, nBF fraction has produced inhibition up to 50.71 ± 0.36% in case of RBC
membrane lysis method with IC50 value 931.18 ± 3.82 (p<0.001), while 53.03 ± 1.06%
inhibition with IC50 value 928.08 ± 20.50 (p<0.001) was found in the case of anti-protein
denaturation. Study first time demonstrated the in-vitro anti-inflammatory and anti-arthritic
potential of the T. pallida leaf.

Keywords: Pergularia pallida; anti-arthritic activity; denaturation; inflammation; HRBC.


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