WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

STRESS DEGRADATION STUDIES ON DARUNAVIR ETHANOLATE USING VALIDATED STABILITY-INDICATING HIGHPERFORMANCE THIN-LAYER CHROMATOGRAPHY

Palak G. Chaudhary and Prof. Dr. Dhrubo Jyoti Sen

ABSTRACT

Darunavir Ethanolate is a novel nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI). A sensitive, selective, accurate, precise and stability-indicating high-performance thin-layer chromatographic method for analysis of Darunavir Ethanolate has been developed and validated. The method uses aluminum-backed silica gel 60F254 plates with toluene – ethyl acetate – methanol 6.5:2.0:1.5 (v/v) as mobile phase. The system gave compact bands for Darunavir Ethanolate (RF 0.37). Densitometric analysis of Darunavir Ethanolate was performed in absorbance mode at 270 nm. The method was linear in the range of 500-3500 ng/band (R2 = 0.9995). The limits of detection and quantification were 130 and 390 ng per band, respectively. Darunavir Ethanolate was subjected to different stress conditions – acid and alkaline hydrolysis, oxidation, photo degradation and thermal degradation. The degradation products were well resolved from the pure drug with significantly different RF values. Since the method could effectively separate the drug from its degradation products, it could be used as a stability-indicating method for analysis of Darunavir Ethanolate.

Keywords: Darunavir Ethanolate (DRV), HPTLC, Stress degradation, Validation, Limit of Detection (LOD), Limit of Quantitation (LOQ), RSD, ICH.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More