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Abstract

FORMULATION AND EVALUATION OF BILAYERED TABLETS OF DICLOFENAC SODIUM AND ESOMEPRAZOLE MAGNESIUM- A DUAL THERAPY FOR PEPTIC ULCER

Pasam Jyothirmayi*, Sonti Madhavi and E. Pratap

ABSTRACT

Objective: To formulate a dual therapy of peptic ulcer containing NSAID, Diclofenac sodium and anti-secretary agent Esomeprazole magnesium utilizing the concept of bilayer tablet system which contains Diclofenac sodium as sustained release layer and Esomeprazole magnesium as immediate release layer for the effective treatment gastric/duodenal ulcer. Method: The sustained release layer of Diclofenac sodium was prepared by wet granulation technique using polymers like HPMC K15 and Xanthan gum in different concentrations. Sodium bicarbonate was used as a gas generating agent. Immediate release layer of Esomeprazole magnesium was prepared by wet granulation technique using super disintegrants. Results: Formulated bilayered tablets were characterized for different parameters like hardness, friability, thickness, weight variation, segregation time, disintegration time, floating lag time and % Cumulative drug release. Conclusion: The results of the evaluation tests indicated that the optimized formulation SF1 showed desired release along with and good disintegration time and desired release rate for the Esomeprazole layer. Different formulations were prepared among the formulations the best formulation shows maximum amount of drug release with in12hrs of time period.

Keywords: NSAIDS, Bilayered tablets, Diclofenac sodium, Esomeprazole magnesium.


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