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Abstract

ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF ETHANOL EXTRACT OF ENANTIA CHLORANTHA STEM-BARK IN RODENTS

Bassey Augustine Ini Lawrence* and Nwafor Paul Alozie

ABSTRACT

Aim of study: To determine the anti-inflammatory, analgesic and antioxidant activities of ethanol extract of the stem bark of Enantia chlorantha in rodents in Akwa Ibom State Nigeria. Materials and methods: A one percent solution of carrageenan, xylene and fresh egg albumin were used in-vivo to test inflammation in Swiss albino mice. Acetic acid (0.1ml of 3% solution), 2.5% formalin solution (0.9% formaldehyde) made up in phosphate buffer solution (PBS concentration: NaCl 137 mM; KCl 2.7 mM and phosphate buffer 10 mM) and an electronic hot plate kept at 45± 10C throughout the experiment was used to evaluate the analgesic properties of the extract. The free radical scavenging ability of the extract against 1-Diphenyl-2- Picrylhydrazyl radical (DPPH) in methanol was evaluated. Results: The extract showed significant (p<0.01-0.001) dose-dependent reduction in inflammation in carrageenan induced edema and fresh egg albumin induced edema relative to control. The standard drug used was acetyl salicylic acid. The xylene induced inflammation experiment showed that the extract exerted significant (p<0.01) anti-inflammatory effect at its highest dose. Analgesic effects of the extract were significant (p<0.05-0.001 relative to control) and dose dependent in all three (3) models. The extract exhibited radical scavenging activity. The IC50 values were: 45.60 μg/ml for the extract and 40.76 μg /ml for ascorbic acid. Conclusion: The above results provide support for the traditional use of Enantia chlorantha stem bark in treating pain and inflammatory conditions in Akwa Ibom state.

Keywords: Enantia chlorantha, stem bark, rodents, ethanol extract.


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