WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

IN SILICO MOLECULAR DOCKING STUDIES OF SOME ISOLATED COMPOUNDS FROM PISTIA STRATIOTES FOR Α-AMYLASE INHIBITORY ACTIVITY.

Md. Imam Hossain Bhuiyan, Md. Kaiser Alam, Mohammad Forhad Khan, Md. Hosne Mobarak Chowdhury, Md. Mohaiminul Islam, Md. Ismail Hossain, Roni Kanti Nath, Nishan Chakrabarty, Mohammad Shah Hafez Kabir*, Kazi Ashfak Ahmed Chowdhury

ABSTRACT

The aim of the study to find the mechanism of action of the isolated
compounds from Pistia stratiotes was explored the α-amylase
inhibitory activity by molecular docking analysis used for three
phytoconstituents namely beta-sitosterol, daucoterol and sitoindoside I
isolated from P. stratiotes, to identify whether these compounds
interact with the responsible protein (α-amylase enzyme). α wide range
of docking score found during molecular docking. Beta-sitosterol,
daucoterol and sitoindoside I showed the docking score -3.783, -3.526
and -5.322 respectively. Among all the compounds, sitoindoside I
showed best docking score, glide emodel and glide energy and it might
be highly considered as safe drug for human. Further in vivo
investigation need to identify whether isolated compounds from P. stratiotes have α-amylase
inhibitory activity or not.

Keywords: Pistia stratiotes ?-amylase, molecular docking, ADME/T properties.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More