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Abstract

TINIDAZOLE MATRIX TABLETS EMPOYING EUDRAGIT S 100 USING KOLLIDON SR FOR COLON SPECIFIC DELIVERY

B. Srinivasa Rao*, Prof. J. Vijaya Ratna and Ch. Taraka Ramarao

ABSTRACT

Colon specific drug delivery has gained increased delivery of drug in the treatment associated with the colon as a potential system for the systemic delivery of the therapeutic peptides and proteins. The absorption of the drug in the upper portion of the GI tract can be minimized until the drug reaches the proximal colon. The matrix tablets each can prepare by direct compression method. All the tablets were found to be non-disintegrating in acidic (pH1.2) and alkaline (pH7.4) fluids, the prepared tablets were of good quality with to drug content, hardness and friability. As the tablets formulated were nondisintegrating in acidic and alkaline fluids, they are considered suitable for colon targeting. From the drug release study it may be concluded that the (TK3) E3 formula of tinidazole matrix tablets have given the desired release profile by showing a minimal release during the lag period of 5 hrs and complete release at the end of 12 hrs. For the optimised formula (TK3) E3 having 25% kollidonSR with 10% of channelling agent (EudragitS100 to that of kollidon SR) showed minimal release in the lag period of 5 hours about 29.1% and 98.2% of the drug was released by the end of the 12h. The tinidazole matrix tablets formulated by employing kollidonSR and various channelling agents showed nonfickian diffusion mechanism and followed zero order kinetics. Matrix tablets (TK3) E3 formulated employing 25% kollidonSR and 10% eudragit S100 are best suited to be used for colon targeting of tinidazole.

Keywords: Channelling agent, Eudragit S 100, Colon Target, KollidonSR, Tinidazole.


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