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Abstract

LOCAL ANTI-INFLAMMATORY AND ANTINOCICEPTIVE ACTIVITIES OF PORTULACA QUADRIFIDA LINN

Manivannan Ekambaram*, Vijayarangan Sivasamy, Kothai Ramalingam, Arul Balasubramanian

ABSTRACT

The ethanolic extract of Portulaca quadrifida was studied in Swiss albino mice against 12-o-tetradecanoyl phorbhol-13-acetate (TPA) and arachidonic acid (AA) induced anti- inflammatory response. While the analgestic effects were studied using the acetic acid induced writhing the mice and formalin induced nociception. The ethanolic extract produced dose dependent anti-inflammatory activity against the pathogens. It also showed an inhibitory effect on pain caused by acetic acid in mice and reduced pain episodes induced by formalin. The result indicated that the ethanolic extract produced significant (p<0.05) anti-inflammatory andanti nociceptive activity when compared with the standard and untreated control.

Keywords: Portulaca quadrifida; ethanolic extract; antiinflammatory; anti-nociceptive.


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