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Abstract

N/S/O FUNCTIONALIZED LIGANDS AND THEIR METAL COMPLEXES: SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES

K. H. Kumar Naik, Nagaraja Naik*

ABSTRACT

A few N/S/O functionalized ligand was prepared from condensation of Boc protected gabapentin drug with different amino acids from coupling reaction method. Ligand form 1:1 complexes with Cu(II), Co(II), Mn(II), Sr(II) and Cd(II) in good yield. Characterizations of the ligand and metal complexes have been done from Elemental analysis, Infrared spectra, 1H NMR, Electronic absorption spectra and molar conductance measurements. Antioxidant and Antimicrobial activity of prepared ligand and metal complexes has been carried out by using DPPH assay. The results suggested that the prepared complexes posses significant activities comparable to the standards.

Keywords: N/S/O donor ligands, Metal complexes, Antioxidant activity, Antimicrobial activity.


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