WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF GASTRORETANTIVE FLOATING TABLET USING EUDRAGIT RSPO WITH NATURAL POLYMERS

Kamlesh J. Wadher*, Shrikant W. Bute and Milind J. Umekar

ABSTRACT

The present study involved the design of gastro retentive floating matrix tablets of weakly basic drug Domperidone by using combination of Eudragit RSPO with natural polymers Guar and Xanthan Gum. The tablets were prepared by wet granulation process. The prepared tablets were investigated for the pre-compression and post-compression parameters. FTIR and DSC studies proved that no chemical interaction in Domperidone and polymers. All the batches evaluated for swelling and floating properties also, the batches containing combination of Eudragit RSPO with natural polymers Guar and Xanthan Gum shows good swelling properties since natural gums swells rapidly and efficiently in water. The in-vitro drug release studies revealed the drug release from the formulation depended upon the polymer concentration and the polymer used. The sustained drug release with better floating was achieved with natural polymers. The developed floating tablet of Domperidone used to prolong drug release for more than 12 hrs, thereby improving bioavailability and better patient compliance. The best fitting model for all formulation was calculated. The plain polymer batches F1- F3, the best fitted models was found to be Higuchi release. The batch F4-F9 batches followed Korsmeyer peppas model.

Keywords: Domperidone, Floating tablets, Eudragit RSPO, Natural polymers, Release kinetics.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More