WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

SIMULTANEOUS ESTIMATION OF PARACETAMOL AND ACECLOFENAC IN TABLET DOSAGE FORM USING UV SPECTROSCOPY

Chaudhari S., *Nimbekar T., Wanjari B., Katolkar P.

 

ABSTRACT

The present study deals with UV spectrophotometric method development & validation for estimation of Paracetamol & Aceclofenac in bulk drug & tablet dosage form by viedort’s method & first order UV derivative spectrophotometry. The vierodt’s method involves measurement of absorbance at λmax of Paracetamol & Aceclofenac at 248 nm & 276 nm respectively. The linearity of paracetamol and aceclofenac was found to be 3-30μg/ml and 2-20 μg/ml respectively. The % recovery of Paracetamol & Aceclofenac was found out to be 99.72 % & 99.69 %s respectively. First order UV derivative spectrophotometry (D1 method), the zero crossing method was chosen as paracetamol could be easily analyzed without any interference from Aceclofenac and vice-versa. Paracetamol was determined by measurement of its D1 amplitude at the zero crossing point of Aceclofenac at (276 nm), While Aceclofenac was determined by measurement of its D1 amplitude at zero crossing point of Paracetamol at (248 nm) Result of tablet analysis indicated that there was no interference of the common excipients used in the tablet formulation. Validation of this method is done as per ICHQ2B guidelines. The proposed method is highly sensitive and successfully applied for the analysis of Aceclofenac and Paracetamol in tablet formulation.

Keywords: Paracetamol, Aceclofenac, Derivative spectroscopy, Validation


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More