Abstract

SYNTHESIS AND CHARACTERIZATION OF NOVEL HETEROCHELATE COMPOUNDS CONTAINING PYRIMIDINE AND 8-HQ

Ajay Solanki and Dr. S. V. Patel*

ABSTRACT

6-methyl-4-(8-hydroxyquinolin-5-yl)-6-methyl-2-oxo-1,2,3,4- tetrahydropyrimidine-5-carboxylate (PYHQ), react with p-toluidine yield 4-(8-hydroxyquinolin-5-yl)-6-methyl-2-oxo-N-p-tolyl-1,2,3,4- tetrahydropyrimidine-5-carboxamide (PYTHQ). The synthesized ligand characterized by elemental analysis and spectral studies. The transition metal chelates of Cu2+, Ni2+ , Co2+ , Mn2+ and Zn2+ of PYTHQ were prepared and characterized by metal-ligand (M:L) ratio, IR and reflectance spectroscopies and magnetic properties. The PYTHQ and its metal chelates were screened for antifungal activity against various fungi.

Keywords: 5-formyl-8-hyroxy quinolinol, Pyrimidine derivative, Magnetic moment and Antifungal properties.