SYNTHESIS AND CHARACTERIZATION OF NOVEL HETEROCHELATE COMPOUNDS CONTAINING PYRIMIDINE AND 8-HQ
Ajay Solanki and Dr. S. V. Patel*
ABSTRACT
6-methyl-4-(8-hydroxyquinolin-5-yl)-6-methyl-2-oxo-1,2,3,4-
tetrahydropyrimidine-5-carboxylate (PYHQ), react with p-toluidine
yield 4-(8-hydroxyquinolin-5-yl)-6-methyl-2-oxo-N-p-tolyl-1,2,3,4-
tetrahydropyrimidine-5-carboxamide (PYTHQ). The synthesized
ligand characterized by elemental analysis and spectral studies. The
transition metal chelates of Cu2+, Ni2+ , Co2+ , Mn2+ and Zn2+ of
PYTHQ were prepared and characterized by metal-ligand (M:L) ratio,
IR and reflectance spectroscopies and magnetic properties. The
PYTHQ and its metal chelates were screened for antifungal activity
against various fungi.
Keywords: 5-formyl-8-hyroxy quinolinol, Pyrimidine derivative, Magnetic moment and Antifungal properties.
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