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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

SYNTHESIS AND EVALUATION OF ANTIMICROBIAL & ANTIFUNGAL ACTIVITY OF NOVEL 1-CYCLOPROPYL-6 - FLUORO-7-(SUBSTITUTED AZOLE AND FUSED AZOLE)-1, 4- DIHYDRO-8-METHOXY-4-OXOQUINOLINE-3-CARBOXAMIDE DERIVATIVES

Zaki Ahmed B. Munshi and Bhata R. Chaudhari*

ABSTRACT

One pot synthesis of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8- methoxy-4-oxoquinoline-3-carboxamide was carried out by reacting 1- cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3- carboxylic acid with simple reagent and condition. Different novel derivatives of 7-substituted 1-cyclopropyl-6 -fluoro-1, 4-dihydro-8- methoxy-4-oxoquinoline-3-carboxamide were synthesized by substituting fluoro group at C-7 position with different azoles and fused azoles. These novel compounds were examined for their antibacterial and antifungal activities.

Keywords: Quinolones, Nalidixic acid, Carbonyldi imidazole, Antimicrobial.


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