Abstract

SYNTHESIS AND EVALUATION OF ANTIMICROBIAL & ANTIFUNGAL ACTIVITY OF NOVEL 1-CYCLOPROPYL-6 - FLUORO-7-(SUBSTITUTED AZOLE AND FUSED AZOLE)-1, 4- DIHYDRO-8-METHOXY-4-OXOQUINOLINE-3-CARBOXAMIDE DERIVATIVES

Zaki Ahmed B. Munshi and Bhata R. Chaudhari*

ABSTRACT

One pot synthesis of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8- methoxy-4-oxoquinoline-3-carboxamide was carried out by reacting 1- cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3- carboxylic acid with simple reagent and condition. Different novel derivatives of 7-substituted 1-cyclopropyl-6 -fluoro-1, 4-dihydro-8- methoxy-4-oxoquinoline-3-carboxamide were synthesized by substituting fluoro group at C-7 position with different azoles and fused azoles. These novel compounds were examined for their antibacterial and antifungal activities.

Keywords: Quinolones, Nalidixic acid, Carbonyldi imidazole, Antimicrobial.