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Clinton Baby, Avinash M., Anjusha A. K., Akhil Babu and Neethu J.*


Is there a revolution afoot in diagnostic medicine? Could a credit cardsized, disposable cartridge and a toaster-sized analyser use artificial intelligence (AI) to digitize biology—detecting and diagnosing sickness instantly even before the patient was aware of it? That is the promise from p-BNC, the programmable bio – nano chip. The Programmable Bio-Nano-Chip System, p-BNC, currently under development, is a credit card sized disposable device that works in conjunction with a toaster sized imaging platform that analyses biomarkers found in bodily fluids and relays complex test results to consumers through an intuitive smart phone interface. The evolving approach is currently being validated by six major clinical trials in the areas of cardiac heart disease, oral cancer, prostate cancer, ovarian cancer and drug of abuse testing. The technology has the potential to diagnose in minutes what previously took labs, hours or days. Each p-BNC cartridge has etched wells containing one bead per well. The beads, coated with antibody or antigen, serve as immobilized capture reagents. Again, versatility is the key principle—they can be used for cell counting (think flow cytometer on a chip), cytology (high-content, single cell analysis), and cell analysis for environmental applications. The utility of p-BNC technology combined with clinical decision support systems (CDSS) has already been demonstrated in establishing a ―cardiac score-card that combines results from 14 biomarkers and other cardiovascular risk factor data into a clinical decision support tool; in diagnosis of prostate, ovarian, and oral cancers; and in detecting multiple drugs of abuse by a single analysis of oral fluid. Combining multiple such ―score-cards, each person could have easily understandable and interpretable personalized wellness data, accessible to themselves and their care-givers through smartphones or any medium they choose.

Keywords: p-BNC, CDSS, score card.

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