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L. Karpagavalli*, K. Gopalasatheeskumar, N. Narayanan, A. Isakki Raj, J. Hari Priya and S. Janarthanan


The history of nasal drug delivery dates back to earlier topical applications of drugs intended for local effects. Nasal therapy also called ‘Nasya karma’ has been recognized form of treatment in the Ayurvedic system of Indian medicines. In this review was study of the nasal drug delivery system as these system is have better systemic bioavailability through nasal route as compared to oral route of administration. The main benefit of using nasal delivery is prevention of first pass metabolism, high permeability of some drugs in nasal epithelium, quick drug absorption across this membrane, rapid onset of action, better patient compliance and comfort, sustained and prolonged action in comparison to other drug delivery systems. Nasal route is alternative to parenteral therapy and also useful for long term therapy. In this review was concentrated on anatomy and physiology of nose, advantages, disadvantages, limitations, mechanism of drug delivery to the nose, types of dosage form for nasal delivery, factors influencing nasal absorption, advancement in nasal dosage form and novel nasal drug formulations.

Keywords: Nasal route, Mucoadhesion, Novel dosage form, CNS Delivery, first pass metabolism.

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