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Abstract

ANTI-DIABETIC ACTIVITY OF METHANOLIC EXTRACT OF WATTAKAKA VOLUBILIS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Udhayasankar M. R.*, Nantha Kumar R., Abdul Kaffoor H. and Arumugasamy K.

ABSTRACT

Wattakaka volubilis(Linn. F.) Benth ex. Hook f. (Asclepidaceae) is a well-known medicinal plant and is used in various human ailments. In the present study investigated methanolic extract of W. volubilis for 21 days on the functions of hyperglycemia, hyperinsulinemia, hyperlipidermic and serum hepatic marker enzymes were evaluated with STZ induced diabetic mellitus in male wistar albino rats. They showed results that a significant increase in the levels of blood glucose, urea, creatinine and glycosylated Hb and decrease in the level of plasma insulin in the diabetic control rats were observed. A reduce in the activities of serum protein, albumin and globulin in diabetic rats and these levels were increased in W. volubilis treated groups III &IV. The marker enzymes SGPT, SGOT and ALP levels were significantly elevated in the STZ treated groups and compared to normal. The groups treated with W. volubilis methanolic extracts showed significantly decrease in the serum marker enzymes. The antidiabetic effect of W. volubilis extract was compared with a standard antidiabetic drug glibenclamide. It is concluded that methanolic extracts of W. volubilis possesses significant antidiabetic, antihyperlipidaemic and antioxidant effects in STZ induced diabetic rats.

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