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Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE FLOATING TABLETS OF VALSARTAN

Amrit Khanal, Mina Bhatta, Sajan Maharjan, T. Suguna and C. Sowmya*

ABSTRACT

Objective: The objective of the study was to develop and evaluate the gastro retentive floating drug delivery system (GFDDS) of Valsartan to achieve prolonged release in the treatment of hypertension and myocardial infections. Methods: The sustained release floating formulations were prepared by direct compression method using HPMCE15, HPMCK15 and Carbopol polymers in various ratios and gas generating agents (Sodium bicarbonate and Citric acid) MCC. FTIR and DSC studies indicates absence of any interaction between Valsartan, polymers and excipients. Results: The tablets were also evaluated for its hardness, friability and other in vitro evaluation tests. All parameter complied with IP limits. The invitro drug release profiles obtained for F8 prepared by combination of HPMCE15, HPMCK15, Carbopol showed lesser floating time(FLT) 3minutes and prolong floating duration and was a controlled release characteristic(98.87%) for 20 hours. The drug release data were analyzed as per zero order (0.951) and first order (0.997) models. Drug release was diffusion controlled and followed first order kinetics. Non-Fickian diffusion was the drug release mechanism from all the tablets formulated. Conclusion: It can be concluded that the gastro retentive floating tablets of valsartan were prepared and evaluated for once daily administration.

Keywords: Floating drug delivery system, Valsartan, HPMC, Carbopol, Floating time, Floating lag time.


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